Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences
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Zhong Nan Da Xue Xue Bao Yi Xue Ban · Feb 2005
Randomized Controlled Trial[Effects of fentanyl on cytokines and MDA during cardiopulmonary bypass in patients undergoing valve replacement].
To investigate the effect of fentanyl on cytokines and MDA in valve replacement surgery during cardiopulmonary bypass ( CPB). ⋯ CPB leads to a proinflammatory and antiinflammatory response, as well as oxygen free radicals release. Larger dose fentanyl seemed to be effective in reducing CPB-induced inflammatory response and ischemic reperfusion injury, but the effect was not dependent on dose while fentanyl dose reaching some value, at the same time the duration of stay in ICU and time of endotracheal extubation is longer.
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Zhong Nan Da Xue Xue Bao Yi Xue Ban · Feb 2005
Randomized Controlled Trial[Clinical research of hyperbaric, isobaric, and hypobaric solutions of bupivacaine in continuous spinal anesthesia].
To compare the anesthesia properities of hyperbaric bupivacaine with those of isobaric and hypobaric solutions when administered in the supine position undergoing hip surgery or lower limb surgery using continuous spinal anesthesia. ⋯ The 0.375% Isobaric bupivacaine used during contiuous spinal anesthesia in the supine position produces a suitable and a more "controllable" anesthesia, but a minimum dosage of 10 approximately 12.5 mg is required to obtain adequate anesthesic conditions with moderate hemodynamic changes and satisfying analgesia effects. Under similar conditions, 0. 375% hyperbaric bupivacaine produces major hemodynamic consequences with high cephalad spread and 0. 375% hypobaric bupivacaine has a too long onset time.
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Zhong Nan Da Xue Xue Bao Yi Xue Ban · Feb 2005
Randomized Controlled Trial[Clinical research on BIS for monitoring the depth of N2O and desflurane anesthesia].
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Zhong Nan Da Xue Xue Bao Yi Xue Ban · Feb 2005
[Behaviorial observation of ropivacaine in continuous spinal anesthesia and Ca2+ content of spinal cord in rats].
To observe the behaviour and Ca2+ content of spinal cord in rats after continuous spinal anesthesia administration of different densities and doses of ropivacaine in SD rats. ⋯ There is no significant change of motor black time and it is related to drug dose for 0.5% , 0.75% and 1% ropivacaine in continuous spinal anesthesia. 1% ropivacaine may increase Ca2+ content in spinal cord.
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Zhong Nan Da Xue Xue Bao Yi Xue Ban · Dec 2004
[Effect of focal hypothermia on traumatic brain edema and the content of lactic acid in the brain tissue in rats].
Objective To investigate the effect of focal hypothermia (LH) on traumatic brain edema and the content of lactic acid in rat brain tissue. ⋯ Focal hypothermia with water of 10 degrees C, 20 degrees C, and 25 degrees C but not 0 degrees C has some effect on traumatic brain edema and the temperature at 20 degrees C and 25 degrees C are the better. The mechanism of focal hypothermia may be associated with inhibiting acidosis of lactic acid.