Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences
-
Zhong Nan Da Xue Xue Bao Yi Xue Ban · Oct 2017
[Mechanism of lung cancer and chronic obstructive pulmonary disease].
Lung cancer and chronic obstructive pulmonary disease (COPD) are both serious threats to human health, resulting in a heavy economic burden for the society. Epidemiological studies have shown that lung cancer and COPD have a high comorbid rate. Cigarette smoking is a congenerous risk factor for both lung cancer and COPD, and may lead to these diseases by triggering certain similar pathways. The common pathogenesis of lung cancer and chronic obstructive pulmonary disease involves premature pulmonary failure, oxidative stress and inflammation, telomere length, genetic susceptibility, and epigenetics.
-
Zhong Nan Da Xue Xue Bao Yi Xue Ban · Aug 2017
[Manifestations of the connective tissue associated interstitial lung disease under high resolution computed tomography].
To analyze the features of the connective tissue associated interstitial lung disease (CTD-ILD) by high resolution computed tomography (HRCT). Methods: A total of 127 patients with CTD-ILD, who were diagnosed by clinic laboratory examination and pathology in Xiangya Hospital of Central South University form September 2013 to September 2015, were enrolled for this study. Their lung features of HRCT imaging were retrospectively analyzed. Results: The classifications for 127 patients were as follows: 36 cases of rheumatoid arthritis (28.3%), 34 cases of dermatomyositis and polymyositis (26.8%), 31 cases of systemic sclerosis (24.4%), 18 cases of Sjögren syndrome (14.2%), 7 cases of mixed connective tissue disease (5.5%), and 1 cases of systemic lupus erythematosus (0.8%). ⋯ The HRCT findings for 36 cases of rheumatoid arthritis associated interstitial lung disease were UIP (24 cases, 66.7%) and NSIP (12 cases, 33.3%); the HRCT findings for 34 cases of dermatomyositis and polymyositis associated interstitial lung disease were NSIP (32 cases, 94.1%), UIP (1 case, 2.9%) and COP (1 case, 2.9%); the HRCT findings for 31 cases of systemic sclerosis associated interstitial lung disease were NSIP (21 cases, 67.8%), UIP (9 cases, 29%), LIP(1 case, 3.2%); the HRCT findings for 18 cases of Sjögren syndrome associated interstitial lung disease were NSIP (9 cases, 50.0%), UIP (8 cases, 44.4%), LIP (1 case, 5.6%); the HRCT findings for 7 cases of mixed connective tissue disease associated interstitial lung disease were UIP (4 cases, 57.1%), NSIP (3 cases, 42.9%). SLE-ILD was rare, with only 1 case of AIP. Conclusion: Different types of CTD-ILD patients display relatively unique manifestation of HRCT.
-
Zhong Nan Da Xue Xue Bao Yi Xue Ban · Aug 2017
[Role of autophagy in ameliorating sepsis-induced acute lung injury by allicinin in mice].
To investigate roles of autophagy in ameliorating sepsis-induced acute lung injury by allicinin in mice. Methods: A total of 152 male Balb/c mice (8-week old) were randomly divided into a sham group, a septic model group, an allicin treatment group, and an autophagy inhibition group. Septic mouse model was established by cecal ligation and puncture (CLP). Mice in the allicin treatment group were given allicin (30 mg/kg, intra-peritoneal injection) at 6 and 12 h, while those in the autophagy inhibition group were given autophagy inhibitor 3-MA (15 mg/kg, intra-peritoneal injection) at half an hour after allicin administration. ⋯ The expression of LC3B and Beclin-1 was determined by immunohistochemical analysis. Results: Compared with the sham group, the 7 d survival rate and lung SOD activity were decreased in the CLP group (P<0.05); the lung morphological damage score, the levels of TNF-α and IL-6 in the BALF, MDA content in the lung, and expression of LC3B and Beclin-1 were increased greatly in the CLP group (P<0.05). Compared with the CLP group, the 7 d survival rate, lung SOD activity and the expressions of LC3B and Beclin-1 were increased significantly in the allicin treatment group (P<0.05); the lung morphological damage scores, the levels of TNF-α and IL-6 in the BALF and MDA content in the lung were decreased obviously in the allicin treatment group (P<0.05). Compared with the allicin treatment group, the 7 d survival rate, lung SOD activity, and the expressions of LC3B and Beclin-1 were decreased in the 3-MA group (P<0.05); the lung morphological damage scores, the levels of TNF-α and IL-6 in the BALF, and MDA content in the lung were increased significantly in the 3-MA group (P<0.05). Conclusion: Allicin may ameliorate sepsis-induced acute lung injury in mice by enhancing the level of autophagy.
-
Zhong Nan Da Xue Xue Bao Yi Xue Ban · Jul 2017
[Treatment of patellofemoral instability in adolescent by anatomical double-bundle medial patellofemoral ligament reconstruction with double suture anchor technique].
To explore the clinical outcomes of anatomical double-bundle medial patellofemoral ligament (MPFL) reconstruction with double suture anchor technique in treating patellofemoral instability in adolescent. Methods: Twenty-five young people with patellofemoral instability (25 knees) in our department from January 2013 to December 2014 were enrolled for this study. All patients were performed anatomical double-bundle MPFL reconstruction with arthroscopic-assisted suture anchors technique in the patella, and fixed in the femoral socket with absorbable interference screw. All patients are evaluated by different methods, including patient's satisfaction, patellar apprehension test, recurrent subluxation/dislocation, CT assessment of bone tunnel and patellar tilt angle. ⋯ The patellar tilt angle was decreased from 21.6°±2.3° to 10.5°±1.6° (P<0.05); the Lysholm scores was increased from 51.7±5.3 to 93.8±6.5 (P<0.05). Tegner scores was increased from 4.1±1.1 to 5.5±0.6 (P<0.05). Kujala scores was increased from 53.5±6.4 to 94.6±4.3 (P<0.05). Conclusion: Arthroscopic-assisted anatomical double-bundle MPFL reconstruction with the suture anchors technique is a safe, minimal invasive and effective surgical option for treating patellofemoral instability in adolescent.
-
Zhong Nan Da Xue Xue Bao Yi Xue Ban · May 2017
[Role of the autophagy in the treatment of neuropathic pain with pulsed radiofrequency].
To detect the effect of pulse radiofrequency (PRF) treatment on the neuropathic pain established by L5-spinal nerve ligation (SNL) on rats, and to investigate if PRF treatment would affect the expression of autophagy related protein LC3 and autophagy related receptor P62 at the dorsal horn. Methods: A total of 36 male Sprague-Dawley rats were randomly divided into 3 groups: a Sham group, a SNL group, and a SNL+PRF group. The 50% paw withdrawal mechanical threshold (PWMT) was detected at 1 day before and 1, 3, 7, 14 and 28 days post-operation by using Von-Frey filaments. The autophagy related protein LC3 and autophagy related receptor P62 were investigated by Western blot. Results: Compared with the Sham group, the PWMT significantly decreased in the SNL group at each time points (P<0.05); in SNL+PRF group, PRF treatment could elevate the PWMT at the 1st day post-operation and lasted for 28 days (P<0.05). What's more, SNL could elevate the LC3-II and P62 levels at the 7th day post-operation (P<0.05), which were decreased by the PRF treatment (P<0.05). Conclusion: PRF treatment could improve SNL-induced the neuropathic pain, which might be partly due to the regulatory effects on the autophagy levels at the spinal dorsal horn.