Revista médica de Chile
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Revista médica de Chile · Feb 2020
[Coronary artery disease in pre and postmenopausal women. The influence of type 2 diabetes mellitus].
Postmenopausal women have higher severity of coronary heart disease (CHD) than premenopausal women and type 2 diabetes mellitus (T2DM) is an independent risk factor. ⋯ The severity of CHD is higher in postmenopausal women and T2DM is associated with the disease.
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Revista médica de Chile · Feb 2020
Review[Inflammation as a common pathogenic factor in coronary artery disease and depression].
A narrative review of the evidence regarding the role of inflammation in the pathophysiology of coronary heart disease and depression is presented. As a common pathogenic factor, inflammation could explain the frequent association of both diseases. We discuss the benefit of exercise and diet modifications in both conditions and the effectiveness and safety of selective serotonin reuptake inhibitors. Finally, we recommend screening for depressive symptoms in coronary patients and the search of cardiovascular risk factors in people with depression.
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Revista médica de Chile · Feb 2020
Review[Unfolded protein response as a target in the treatment of Alzheimer's disease].
The clinical features of Alzheimer's disease (AD), for example the progressive memory loss, are produced by neuronal loss and synaptic dysfunction. These events have been associated with histopathological alterations in AD brain, including the presence of amyloid plaques and neurofibrillary tangles. Recent studies suggest that cellular stress produced by the aggregation of misfolded proteins leads to alterations in protein homeostasis, that is regulated for the most part by endoplasmic reticulum (ER). ⋯ Based on the involvement of ER stress in several diseases, efforts are being done to identify small molecules that can inhibit or activate selective UPR components. Here, we review the findings suggesting a functional role of ER stress in the etiology of AD. Possible therapeutic strategies to mitigate ER stress in the context of AD are discussed.