Revista médica de Chile
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Revista médica de Chile · Jul 2021
Review[Pharmacokinetic interactions of fruit juices and herbal preparations].
Drug disposition in the human body is strongly influenced by transporters and metabolizing enzymes expressed in key organs including intestine, liver and kidney. Since drugs and chemicals present in foods such as fruit juices and herb-based products are substrates of the above-mentioned proteins, there is a high probability of pharmacokinetic interactions. Findings from preclinical and clinical studies helped to characterize the mechanisms by which the components of fruit juices and herbs act as perpetrators of pharmacokinetic interactions. The aim of this review is to provide an overview of pharmacokinetic fruit juice- and herb-drug interactions that could be relevant in the clinical setting.
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Revista médica de Chile · Jul 2021
[General and infant mortality trends in Chile from 1909 to 2017].
During the twentieth century, Chile experienced an important reduction in general mortality. ⋯ Public health efforts should be carried out to further reduce socioeconomic and regional gaps in adult and infant mortality in Chile.
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Suicide is a public health problem in the world. In Chile, suicide rates increased since 1990 with regional differences in rates. ⋯ The use of geographic methods and the disaggregation of suicide cases at district level, allowed the identification of territorial variability in the distribution of suicide rates within the Araucanía Region. Spatial patterns of areas with high suicide risk were found.
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Revista médica de Chile · Jul 2021
[Physical and emotional sequelae after hospitalization for COVID-19].
Facing a severe life-threatening disease has physical and emotional consequences for patients. ⋯ Patients who survived COVID-19 have a decrease in physical capacity and a significant proportion of depression and anxiety one month after hospital discharge.
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Revista médica de Chile · Jul 2021
[Effects of COVID-19 pandemic on food insecurity perception in Chilean households].
The coronavirus 2 pandemic (COVID-19) has caused intense changes in lifestyles, feeding, and nutrition habits. ⋯ The COVID-19 pandemic in Chile increased the perception of food insecurity in households with vulnerable conditions. However, the consumption of healthier foods increased.