Revista médica de Chile
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Revista médica de Chile · Sep 2021
[Disease genotype, haplotypes, diagnosis and associated studies in sickle cell anemia].
Sickle cell anemia is a type of hemoglobinopathy characterized by a specific mutation in the beta globin gene with the consequent generation of an unstable hemoglobin that crystallizes in a state of hypoxia. This causes a change in the structure of the red blood cell, which ends up producing vaso-occlusion with the corresponding clinical complications for the patient. ⋯ There are new therapeutic alternatives to the use of hydroxyurea and L-glutamine, such as the use of gene therapy tools. The most recent experimental trials are exploring gene editing techniques.
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Revista médica de Chile · Sep 2021
Case Reports[Quantitative electroencephalogram for prediction of delayed ischemia in subarachnoid haemorrhage. Report of one case].
Subarachnoid hemorrhage (SAH) is a devastating disease, with a mortality rate of 35%. Among patients who survive the initial bleeding, the leading cause of morbidity and mortality is delayed cerebral ischemia (DCI). Electroencephalography (EEG) can detect cerebral ischemia in the early stages. ⋯ A second MRI was carried out on the eighth day, which showed a left insular infarction and generalized vasospasm. A second therapeutic angiography was performed; the patient persisted with aphasia and left central facial paresis. The quantitative EEG analysis performed retrospectively showed a generalized reduction in the spectral edge frequency 95 (SEF95; meaning slowing in the EEG signal) at the fourth day of follow up, three days earlier than the clinical and imaging diagnosis of DCI was established.
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Revista médica de Chile · Sep 2021
Observational Study[Risk factors for adverse drug reactions in patients admitted to intensive care units].
Patients hospitalized in intensive care units (ICU) are at higher risk of having adverse drug reactions (ADR). ⋯ The identified risk factors have a great impact on pharmacokinetic and pharmacodynamic parameters, and should be considered to avoid the appearance of ADR.
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Revista médica de Chile · Sep 2021
[Access of chilean deaf women to healthcare information and reproductive care].
The COVID-19 pandemic threatened the accessibility and response of healthcare systems worldwide. People with disabilities face specific access challenges to healthcare services and to healthcare information in accessible formats. ⋯ The pandemic generated a crisis in the Chilean healthcare system that demands a new strategy to ensure people's healthcare access. People with disabilities such as those herein studied are marginalized when these new policies are being discussed and implemented. Decision-makers and sexual and reproductive health services must improve their strategies to allow women with disabilities, particularly deaf women gain access.
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Revista médica de Chile · Sep 2021
[Quality of life of older people with depression and dependence: validity of the SF-12 (short form health survey) questionnaire].
Depression and dependence have a great impact on the quality of life of older people. ⋯ The validity of the SF-12 for measuring HRQoL was demonstrated. People with depression and dependence have a worse physical and mental quality of life.