Revista médica de Chile
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Revista médica de Chile · Jul 2022
Observational Study[Analysis of pre-ablative and preoperative thyroglobulin in differentiated thyroid cancer].
The measurement of plasma thyroglobulin (Tg) is widely used in the monitoring of differentiated thyroid cancer (CDT). In recent years, its value as a prognostic marker prior to ablation with radioiodine has increased, demonstrating its high negative predictive value. Recent studies indicate that a wide variety of factors could potentially influence pre-ablative Tg values, including residual tumor burden and stimulation modality. ⋯ A statistical association between pre-ablative Tg levels and the amount of preoperative tumor tissue burden was found in some subgroups of patients.
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Revista médica de Chile · Jul 2022
Case Reports[Lipase hypersecretion syndrome and bone lesions in acinar cell cancer of the pancreas. Report of one case].
Lipase hypersecretion syndrome (LHS) is a rare paraneoplastic syndrome, associated with acinar cell carcinoma of the pancreas (ACCP) in 10% to 15% of patients. Clinically, LHS manifests itself with the appearance of subcutaneous fibrocystic nodules, associated with trophic changes in the overlying skin, such as ulcers or fistulas that are difficult to manage, mainly affecting the lower extremities. Additionally, lipolysis near the joints and in the intraosseous adipose tissue can cause bilateral arthralgias, especially of the knees and ankles. ⋯ Additionally, a CT scan of the abdomen revealed a significant abdominal mass, measuring approximately 17 cm and in contact with the body and tail of the pancreas, pathologically compatible with an ACCP. Treatment with capecitabine was started with a favorable progression. The patient currently presents a small left lateral retro malleolar fistula, which, given the analyzes, studies and reviewed literature is concluded to be a lesion in the context of LHS.
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Revista médica de Chile · Jul 2022
Observational Study[Search for mutations in patients with Philadelphia negative myeloproliferative neoplasms in a public hospital in Chile].
Philadelphia negative myeloproliferative neoplasms (Ph-MPN) are clonal disorders whose pathogenesis has been elucidated in recent years, creating diagnostic and prognostic algorithms. ⋯ The presentation and frequency of JAK2 V617F, CALR and MPL mutations in our cohort was similar to those reported in other studies for ET and PM. JAK2 V617F mutation was lower for PV. No significant differences between the three MPNs were observed for overall survival. We could not assess the prognostic value of the mutations.
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Revista médica de Chile · Jul 2022
[Combining the national health survey with GES notifications to improve the depression prevalence estimation in Chile].
Major Depressive Disorder (MDD) is a public health problem of increasing severity in Chile. However, prevalence studies of MDD yield discordant results. Reconciling these discordances, at least in part, requires improving the estimate of MDD prevalence in Chile. ⋯ The MDD prevalence that results from combining ENS 2016/17 and GES data is greater than the prevalence reported by the ENS 2016/17 alone. This increase in cases allows policymakers to improve budgeting and implementation of public policies concerning the prevention and treatment of MDD.