World journal of clinical cases
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To determine the role of leukocyte function-associated antigen-1 (LFA-1) in polymicrobial sepsis model in mice. ⋯ LFA-1 deficiency did not attenuate neutrophil recruitment to various organs to adequately mitigate secondary tissue injury in sepsis. It was associated with decreased neutrophil recruitment to the abdominal cavity, higher bacterial load, leading to increased mortality in an abdominal, polymicrobial sepsis.