Southern medical journal
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Southern medical journal · May 2023
ReviewConvalescent Plasma Therapy in Late-State, Severe COVID-19 Infection.
Current evidence favors plasma to be effective against coronavirus disease 2019 (COVID-19) in critically ill patients in the early stages of infection. We investigated the safety and efficacy of convalescent plasma in specifically late-stage (designated as after 2 weeks of hospital admission) severe COVID-19 infection. We also conducted a literature review on the late-stage use of plasma in COVID-19. ⋯ This case series provides evidence that convalescent plasma may be safe and effective in late-stage, severe COVID-19 infection. Results showed clinical improvement posttransfusion as well as decreased all-cause mortality in comparison to pretransfusion predicted mortality. Randomized controlled trials are needed to conclusively determine benefits, dosage, and timing of treatment.
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Southern medical journal · May 2023
ReviewDirect Use of Clinical Tolerance Limits for Assessing the Degree of Agreement between Two Methods of Measuring Blood Pressure.
A large number of new methods of measuring blood pressure (BP) have recently emerged with advances in technology. Different methods of measuring BP generally provide varying readings compared with one another. Clinicians must decide how to respond to these variations and how to assess the degree of agreement. ⋯ This method requires a comparison of Bland-Altman limits with the prespecified clinical tolerance limits. This review describes an alternative simple and robust method that directly uses clinical tolerance limits for assessing agreement without calculating Bland-Altman limits. The many advantages of this method are illustrated with the help of real-life examples of BP measurements.