Mayo Clinic proceedings
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Mayo Clinic proceedings · Nov 2008
Comparative StudyUse of renal function measurements for assessing fracture risk in postmenopausal women.
To determine whether factors associated with moderate chronic kidney disease can be used to independently predict fracture risk in postmenopausal white women by analyzing the effect of adding renal function measurements to traditional risk factors (eg, age, body weight, bone mineral density) for fracture risk assessment. ⋯ The addition of serum creatinine concentration, creatinine clearance rate, or estimated glomerular filtration rate does not improve fracture risk prediction in postmenopausal white women who have moderate chronic kidney disease. This result can be partly explained by the fact that important risk factors for decreased renal function (eg, advanced age, lower body weight) are already accounted for in most fracture prediction models.
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Mayo Clinic proceedings · Nov 2008
Patterns of neuropathy and autonomic failure in patients with amyloidosis.
To define the clinical patterns of peripheral neuropathy and autonomic testing abnormalities in patients with amyloidosis. ⋯ Physicians should test for symptoms of generalized autonomic failure in patients who have peripheral neuropathy of unknown origin. Autonomic testing may give abnormal results in patients without overt symptoms of autonomic failure. Early recognition of autonomic failure may lead to earlier diagnosis of the underlying pathogenesis of amyloidosis, as well as earlier treatment for patients with this condition.