Mayo Clinic proceedings
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Mayo Clinic proceedings · Jan 2013
Randomized Controlled TrialEffects of bisphosphonate treatment on circulating osteogenic endothelial progenitor cells in postmenopausal women.
To evaluate whether bisphosphonates modulate vascular calcification by a modification in endothelial progenitor cells (EPCs) coexpressing osteoblastic surface markers and genes. ⋯ Our findings indicate that bisphosphonate treatment down-regulates the expression of osteogenic genes in EPCs and suggest a possible mechanism by which bisphosphonates may inhibit vascular calcification.