Mayo Clinic proceedings
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Mayo Clinic proceedings · Mar 2013
Randomized Controlled TrialLosartan added to β-blockade therapy for aortic root dilation in Marfan syndrome: a randomized, open-label pilot study.
To assess the tolerability and efficacy of the investigational use of the angiotensin II receptor blocker losartan added to β-blockade (BB) to prevent progressive aortic root dilation in patients with Marfan syndrome (MFS). ⋯ This randomized, open-label, active controlled trial mostly based on a pediatric population demonstrated for the first time that losartan add-on BB therapy is safe and provides more effective protection to slow the progression of aortic root dilation than does BB treatment alone in patients with MFS.