Mayo Clinic proceedings
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Mayo Clinic proceedings · Oct 2014
Review Meta AnalysisThe prognostic importance of weight loss in coronary artery disease: a systematic review and meta-analysis.
To assess the prognostic impact of weight loss on clinical outcomes in patients with coronary artery disease (CAD). ⋯ Whereas observational weight loss is associated with increased adverse cardiovascular events, intentional weight loss is associated with lower clinical events. These results suggest that the underlying mechanism of weight loss (ie, intentional or unintentional) affects its impact on subsequent risk in persons with known CAD.
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Mayo Clinic proceedings · Oct 2014
Multicenter StudyAssociation of coronary artery calcium and coronary heart disease events in young and elderly participants in the multi-ethnic study of atherosclerosis: a secondary analysis of a prospective, population-based cohort.
To evaluate the association of coronary artery calcium (CAC) and coronary heart disease (CHD) events among young and elderly individuals. ⋯ Increased CAC imparts an increased CHD risk in younger and elderly individuals. CAC is highly predictive of CHD event risk across all age groups, suggesting that once CAC is known chronologic age has less importance. The utility of CAC scoring as a risk-stratification tool extends to both younger and elderly patients.
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Mayo Clinic proceedings · Oct 2014
Multicenter StudyPrevalence of multimorbidity in a geographically defined American population: patterns by age, sex, and race/ethnicity.
To describe the prevalence of multimorbidity involving 20 selected chronic conditions in a geographically defined US population, emphasizing age, sex, and racial/ethnic differences. ⋯ Multimorbidity is common in the general population; it increases steeply with older age, has different patterns in men and women, and varies by race/ethnicity.
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Mayo Clinic proceedings · Oct 2014
Observational StudyProspective cohort study of the effectiveness of smoking cessation treatments used in the "real world".
To estimate the "real-world" effectiveness of commonly used aids to smoking cessation in England by using longitudinal data. ⋯ Prescription medication offered with specialist behavioral support and that offered with minimal behavioral support are successful methods of stopping cigarette smoking in England.
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To describe clinical and laboratory findings from the 2012 southeastern Minnesota pertussis outbreak. ⋯ The 2012 pertussis outbreak in southeastern Minnesota included multiple strains of B pertussis, all putatively lacking pertactin. Our findings may indicate decreased efficacy of (and waning immunity from) acellular vaccines as contributors to the outbreak.