Mayo Clinic proceedings
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Mayo Clinic proceedings · Jan 2020
Randomized Controlled TrialEffects of Renal Impairment on the Pharmacokinetics, Efficacy, and Safety of Inclisiran: An Analysis of the ORION-7 and ORION-1 Studies.
To investigate the pharmacodynamic properties of inclisiran, a small interfering RNA targeting proprotein convertase subtilisin-kexin type 9 (PCSK9), in individuals with normal renal function and renal impairment (RI). ⋯ The pharmacodynamic effects and safety profile of inclisiran were similar in study participants with normal and impaired renal function. Dose adjustments of inclisiran are not required in these patients.
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Mayo Clinic proceedings · Jan 2020
Diabetes Mellitus Is an Independent Predictor for the Development of Heart Failure: A Population Study.
To delineate the impact of diabetes mellitus (DM) on the development of cardiovascular diseases in a community population. ⋯ In this cohort, participants with DM have an increased incidence of HF over a 10-year follow-up period even in the absence of underlying diastolic dysfunction. These findings suggest that DM is an independent risk factor for the development of HF and supports the concept of DM cardiomyopathy.
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Mayo Clinic proceedings · Jan 2020
Serum Bicarbonate Concentration and Cause-Specific Mortality: The National Health and Nutrition Examination Survey 1999-2010.
To assess the association between serum bicarbonate concentration and cause-specific mortality in the US general population. ⋯ In a large cohort of US adults, serum bicarbonate concentration level below 22 mEq/L was associated with malignancy-related mortality, whereas a concentration above 26 mEq/L was associated with cardiovascular mortality. Further studies to evaluate potential mechanisms for the differences in cause-specific mortality are warranted.
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Mayo Clinic proceedings · Jan 2020
A Structured Compensation Plan Results in Equitable Physician Compensation: A Single-Center Analysis.
To assess adherence to and individual or systematic deviations from predicted physician compensation by gender or race/ethnicity at a large academic medical center that uses a salary-only structured compensation model incorporating national benchmarks and clear standardized pay steps and increments. ⋯ A structured compensation model was successfully applied to all physicians at a multisite large academic medical system and resulted in pay equity. However, achieving overall gender pay equality will only be fully realized when women achieve parity in the ranks of the most highly compensated specialties and in leadership roles.