Mayo Clinic proceedings
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Mayo Clinic proceedings · Feb 2020
Association Between Income Disparities and Risk of Chronic Kidney Disease: A Nationwide Cohort Study of Seven Million Adults in Korea.
To examine the association between income level and incident chronic kidney disease (CKD) in adults with normal baseline kidney function. ⋯ In this large nationwide cohort, lower income levels were associated with higher risk for incident CKD.
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Mayo Clinic proceedings · Feb 2020
Case ReportsIntegration of Comprehensive Genomic Analysis and Functional Screening of Affected Molecular Pathways to Inform Cancer Therapy.
To select optimal therapies based on the detection of actionable genomic alterations in tumor samples is a major challenge in precision medicine. ⋯ Unlike clinical testing, the combination of tumor profiling, data integration, and functional validation accurately assessed driver alterations and predicted effective treatment.
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Mayo Clinic proceedings · Feb 2020
Development of Global Reference Standards for Directly Measured Cardiorespiratory Fitness: A Report From the Fitness Registry and Importance of Exercise National Database (FRIEND).
To begin the process of developing global reference standards for adults from directly measured cardiorespiratory fitness (CRF). ⋯ This report begins to establish global reference standards for CRF. Continued development of FRIEND-I will increase global representation providing an improved ability to identify and stratify CRF risk categories.
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Mayo Clinic proceedings · Feb 2020
ReviewReexamining the Ethics of Human Germline Editing in the Wake of Scandal.
In November 2018, the announcement that genetically edited human embryos had been used for reproductive purposes caused international uproar; many observers argued that editing the human germline was unethical, particularly given the early stage of the science and the absence of appropriate oversight. We provide an overview of the implications of these events, focusing on the relevant ethical considerations for physicians addressing patient questions and concerns. ⋯ An important question raised by our growing capacity to genetically alter human embryos is how to understand the implicit social contract between science and society. To ensure that translational research continues to enjoy the historic trust placed in scientists and research organizations, it is critical that scientific and health care institutions proactively engage governments, patient advocacy organizations, and the general public in the formation of policies that guide gene editing.
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Mayo Clinic proceedings · Feb 2020
Ultraviolet Radiation Exposure and the Risk of Herpes Zoster in Three Prospective Cohort Studies.
To examine the association between ultraviolet radiation (UVR) exposure and the risk of herpes zoster (HZ) in 3 prospective cohorts. ⋯ Ambient UVR exposure was associated with a higher risk of HZ in men but not in women. A history of severe sunburn was associated with a modest increased risk of HZ in men and women, possibly because of immunosuppression from overexposure to the sun.