Dermatology online journal
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Dermatol. Online J. · Jan 2021
Case ReportsOrf progressiva: giant progressive and destructive infections in the immunocompromised.
Orf virus causes a self-limited infection in humans that resolves without scarring within 6-12 weeks. However, lesions in the immunocompromised can be progressive and disfiguring. The lesions frequently recur after treatment. ⋯ Acyclovir or valacyclovir with imiquimod has been reported to be effective. Two patients achieved cure with imiquimod alone. We summarize these cases to prompt recognition of orf progressiva as a distinct clinical entity that requires treatment.