Helvetica chirurgica acta
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Helvetica chirurgica acta · Mar 1992
Randomized Controlled Trial Clinical Trial[Effect of continuous postoperative analgesia with peridural bupivacaine on intestinal motility following colorectal resection].
In a prospective randomized trial the effects of continuous peridural analgesia on gastrointestinal motility and the postoperative course was studied in 48 consecutive patients with elective colorectal resections. 24 patients had peridural analgesia (PDA) with bupivacaine while 24 patients received intravenous analgesia (IVA) with pentazocine. With PDA the first passage of flatus and faeces was significantly accelerated. PDA was not associated with an increased rate of anastomotic breakdown and there were no respiratory complications in the PDA group.
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Helvetica chirurgica acta · Sep 1991
Randomized Controlled Trial Comparative Study Clinical Trial[Reduction of postoperative blood loss and donor blood use in heart surgery with aprotinin: experience with various dosages].
The effect of high dose aprotinin was evaluated in a prospective study on 100 patients undergoing cardiopulmonary bypass. Special attention was made on postoperative blood loss and transfusions of bank blood postoperatively. In the first part of the study, after induction of anesthesia, a loading dose of 2,000,000 kallikrein-inhibiting-unit (KIU) = 280 mg aprotinin was given intravenously over a 30-min period. ⋯ It appears possible that aprotinin reduces the activation of the coagulation during cardiopulmonary bypass and preserves platelet function without affecting platelet consumption during the extracorporeal circulation. The results of our study demonstrate that high dose aprotinin markedly reduces blood loss as well as homologous blood requirement in the early postoperative course of cardiosurgical patients. Similar effects due to reduced aprotinin dose have been observed in patients receiving aprotinin in the extracorporeal circulation only.
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Helvetica chirurgica acta · Dec 1980
Randomized Controlled Trial Clinical Trial[Antibiotic preparation of the colon or preoperative parenteral prophylaxis in colon surgery. A randomized study].
A double-blind randomised trial was carried out among 72 patients undergoing elective colorectal surgery. 37 patients received Metronidazole and Kanamycin systemically, 35 patients the same medicaments orally. We could not find any difference between the two ways of application. These results are in opposition to those of a comparable study of Birmingham, where the therapy was significantly less successful in the oral group. This fact is discussed and the parenteral, short-term prophylaxis is recommended.