Tidsskrift for den Norske lægeforening : tidsskrift for praktisk medicin, ny række
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Acute liver failure and acute decompensated chronic liver failure are two diseases that demand extensive knowledge of etiology and triggering factors, pathophysiology, diagnosis, prognosis and recommended guidelines for treatment. The article defines the diseases, discusses etiological factors, treatment strategies, indications for referral to the transplantation unit at Rikshospitalet and prognostic factors of importance. ⋯ Patients diagnosed with acute liver failure or acute decompensated chronic liver failure remain a clinical challenge. Optimal treatment requires extensive knowledge of pathophysiological mechanisms and treatment strategies.
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Tidsskr. Nor. Laegeforen. · Aug 2010
[Use of glucosamine does not reduce the need for other pain-relieving drugs].
Since 2004, glucosamine has been available as a prescription drug for symptomatic treatment of mild to moderate osteoarthritis. The aim of this study was to characterize glucosamine utilization patterns, and patients' concomitant use of other analgesics, as well as the prescribers' medical specialty. ⋯ Glucosamine use is not associated with use of less other pain-relieving drugs. This may reflect insufficient clinical effect of glucosamine.
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The opioids morphine and oxycodone are potent analgesics that are available as extended-release and immediate-release tablets. Indications are the same for both; i.e. severe acute pain and chronic pain (non-malignant or malignant). Few clinical studies have compared morphine and oxycodone directly. There is no evidence to support that one is superior over the other.