Harefuah
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Randomized Controlled Trial
[The effect of steroid therapy on post adenotonsillectomy recovery].
Previous studies on dexamethasone's antiemetic and antinflammatory potential in patients undergoing adenotonsillectomy have produced conflicting results. ⋯ Intraoperative injection of I.V. dexamethasone 0.5 mg/kg effectively reduced post adenotonsillectomy morbidity.
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Randomized Controlled Trial Comparative Study Clinical Trial
[A prospective, randomized double-blind study on the treatment of anal fissures with Nitroglycerin ointment].
Anal fissure is a common disease. Treatment includes conservative measures or surgery. One of the treatment options is topical Nitroglycerin ointment. ⋯ According to our study, there was no benefit regarding healing or pain relief, in treating patients suffering from an anal fissure with Nitroglycerin ointment in combination with stool softeners and sitz baths, compared to the same treatment without Nitroglycerin ointment.
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Randomized Controlled Trial Multicenter Study Comparative Study Clinical Trial
[The benefit of combining spinal morphine and intravenous buprenorphine for perioperative pain].
Concurrent administration of opioids with different affinity produces synergistic antinociceptive effect in rats. We tested the perioperative antinociceptive effects of the simultaneous double blind administration of morphine, a pure agonist and buprenorphine, a partial agonist, in 30 patients undergoing hysterectomy under general anesthesia. Pre- and post-operatively regimens consisted of random patient assignment to intrathecal 0.3 mg morphine plus intravenous saline (group 1), intravenous 0.09 mg buprenorphine plus intrathecal saline (group 2) or intrathecal morphine 0.3 mg plus intravenous buprenorphine 0.09 mg (group 3). ⋯ Buprenorphine-induced analgesia in group 3 lasted significantly (P < 0.05) longer than in group 2. Side effects in groups 2 and 3 were by 44% and 42% fewer than in group 1, respectively, with no withdrawal symptoms. Thus, concomitant administration of intrathecal morphine and low dose intravenous buprenorphine produces better and longer pain relief than intravenous buprenorphine alone in women after hysterectomy.