Biochimica et biophysica acta
-
Biochim. Biophys. Acta · Aug 2013
ReviewPunctum on two different transcription factors regulated by PGC-1α: nuclear factor erythroid-derived 2-like 2 and nuclear respiratory factor 2.
The transcription factor nuclear factor-erythroid-derived 2-like 2 (official symbol: NFE2L2, alias: Nrf2) is a master regulator of antioxidant defense system, which makes it an attractive target for manipulations that aim to increase cellular resistance to oxidative stress. Nuclear respiratory factor 2 or GA binding protein transcription factor alpha (official symbol: GABPA, alias: NRF2) functions as a transcription factor that activates the expression of some key metabolic genes regulating cellular growth and nuclear genes required for mitochondrial respiration as well as mitochondrial DNA transcription and replication. ⋯ The comprehension of molecular mechanisms that modulate the intersection between these proteins will be important to identify new signaling axis involved in lifespan extension as well as novel targets for therapeutic interventions.