[Zhonghua yan ke za zhi] Chinese journal of ophthalmology
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Zhonghua Yan Ke Za Zhi · Apr 2013
Review[Recent advances in study of neuroglobin expression in retinal diseases].
Neuroglobin (NGB) is widely exists in the retina and predominantly expressed in the plexiform layers and the inner segments. The physiological roles of NGB may include transportation of oxygen, protection against ischemia/hypoxia injury and oxidative stress, function as a redox-coupled sensor regulating the G-protein coupled transduction pathway, protection against neuronal apoptosis, and working as a terminal oxidase. Based on the function and distribution of NGB and the etiology and pathogenesis of retinal degeneration; it is possible that NGB may play a role in the development of retinal degeneration.
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Zhonghua Yan Ke Za Zhi · Jul 2008
Review[Roles of angiopoietins family and its receptor in the pathogenesis and regulation of corneal neovascularization].
Corneal neovascularization is one of the tough problems in the cornea diseases, but its pathogenesis is still unclear. Binding of angiopoietins family and its receptor Tie2 set up the signal transducing system of Ang/Tie2, which plays the important role in the angiogenesis and regulation. Recently, the study of the signal transducing system of Ang/Tie2 has archived some progression in the corneal neovascularization. So this article reviewed the advances of related role of angiopoietins family and its receptor in the pathogenesis and regulation of corneal neovascularization including the structure and function of angiopoietins and its receptor Tie2.