The journal of allergy and clinical immunology. In practice
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J Allergy Clin Immunol Pract · Nov 2017
Multicenter StudyTreatment Effect and Safety of Icatibant in Pediatric Patients with Hereditary Angioedema.
Clinical manifestations of hereditary angioedema with C1 inhibitor deficiency (C1-INH-HAE) usually begin in childhood, often intensifying during puberty. Currently there are insufficient efficacy/safety data for HAE therapies in children and adolescents due to the small number of pediatric patients enrolled in studies. ⋯ Symptom relief was rapid, and a single icatibant injection in pediatric patients with C1-INH-HAE was well tolerated (ClinicalTrials.gov identifier, NCT01386658).
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J Allergy Clin Immunol Pract · Nov 2017
Randomized Controlled TrialSafety Review of 5-Grass Pollen Tablet from Pooled Data of Clinical Trials.
The 5-grass pollen sublingual tablet has been approved for the treatment of grass pollen-induced allergic rhinoconjunctivitis in subjects with or without intermittent asthma. ⋯ The pooled analysis in 1,514 subjects from 8 clinical studies demonstrates that the 5-grass pollen sublingual tablet has a similar good safety profile in adult and pediatric patients with or without mild, intermittent asthma.
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J Allergy Clin Immunol Pract · Sep 2017
Observational StudyAnaphylaxis in the Pediatric Emergency Department: Analysis of 133 Cases After an Allergy Workup.
Data on the incidence and characteristics of pediatric anaphylaxis are scarce. Reported causes of anaphylaxis are mostly those suspected by the physician in the emergency department (ED), which may not coincide with the real triggers. ⋯ The incidence of anaphylaxis is higher in children than previously reported in adults from the same center, and food is the trigger in most cases. To prevent erroneous diagnoses, the etiology of anaphylaxis should be established after an appropriate workup.
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J Allergy Clin Immunol Pract · Sep 2017
Diagnostic Accuracy of Inflammatory Markers for Diagnosing Occupational Asthma.
The assessment of airway responsiveness and inflammation is key to the investigation of occupational asthma (OA). ⋯ Blood eosinophil counts do not appear to be an effective aid for diagnosing OA. The performance of both sputum cell count analysis and a methacholine challenge before and after exposure to the offending agent may represent an effective alternative in diagnosing OA when SICs are unavailable.
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J Allergy Clin Immunol Pract · Sep 2017
Temporal Trends in Epinephrine Dispensing and Allergy/Immunology Follow-up Among Emergency Department Anaphylaxis Patients in the United States, 2005-2014.
Anaphylaxis is a potentially life-threatening allergic reaction; measures including prescription of an epinephrine autoinjector (EAI) and allergy/immunology (A/I) follow-up may prevent future morbidity. ⋯ Over the past decade, rates of EAI dispensing and A/I follow-up after an ED visit for anaphylaxis have remained low, suggesting that patients may not be prepared to manage future episodes.