Allergie et immunologie
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Allergy to mosquitoes that produces anaphylaxis is very exceptional. We present two observations of anaphylaxis to mosquitoes with good correlation between the clinical history and the immunological indications of which the basophil activation test proved to be effective. The many allergens of mosquitoes are contained in the juices and salivary glands and their molecular weights are between 22 and 95 kD. Specific immunotherapy, which uses whole body extracts of mosquito, gives good results of protection that induces excellent tolerance and has very good efficacy.
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The authors describe for the first time the Wasp/Mosquito syndrome. The allergenic cross-reactivity between Vespula wasp venom and mosquito extract and the reverse rest objectively on several criteria. The frequency of the association between sensibilization to Vespula wasp venom and mosquito: In 10 subjects who had specific IgE to Vespula wasp venom 3 also had mosquito-specific IgE (30%), but out of 11 subjects with positive mosquito-specific IgE 10 also were positive with Vespula wasp venom specific IgE (about 91%). ⋯ W. of the order or 42KD and isoelectric point between 4.5 and 5. An immunoblot study identified this common protein with a M. W. of 44KD which is the same as hyaluronidase.
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Allergie et immunologie · May 1999
Comparative StudyAnaphylaxis in schools and other child-care settings--the situation in France.
The American Academy of Allergology and Clinical Immunology joined to the Canadian Society published in August 1998 guidelines for the management of anaphylaxis in schools. The authors assess the situation in France. An emergency health care form entitled "Projet d'Accueil Individualisé", is carried out by allergologists, and countersigned by the physician in charge of the School Health Department. ⋯ Beta adrenergic drugs are advised on the account of severe attacks of asthma. School lunches being not safe are not allowed. Civil society's liability is a question that has not yet been solved.
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Allergie et immunologie · Nov 1998
Case Reports[Importance of realistic tests for drug allergy: apropos of a clinical case].
Drug allergy is the most difficult area in Allergology because: Clinical polymorphism and specially physiopathology (IgE-dependent hypersensibility reaction, cyclo-oxygenase inhibitor, etc.). Feeble specificity and sensitivity in the basic immunoallergic investigation (Skin tests, specific IgE). Very frequently his necessitates recourse to REALISTIC TESTS of drug re-introduction under clinical and biological surveillance (HSI mediators: histamine/tryptase/urinary methyl histamine) to produce a diagnosis.
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Allergie et immunologie · Sep 1998
Comparative Study[Comparison of the levels of histamine, tryptase, and interleukin-6 for the investigation of anaphylactoid drug reactions].
The biological exploration of the anaphylactoid reaction is based on tryptase and plasma histamine determinations. As this reaction may be considered as a particular case of the acute inflammatory reaction, we have compared, on 25 subjects having presented a drug induces anaphylactoid reaction grade 1 to 3 the plasma level of tryptase, histamine and interleukin 6 (IL6) at 30 and 90 min. ⋯ Correlation between IL6 and the two parameters was only significant for tryptase at 30 and 90 min. Due to the longer lasting kinetic of IL6 (48 h) as compared to histamine and tryptase, IL6 could have a place in the immediate exploration of the anaphylactoid reactions, these results having to be completed by studies on a longer delay and on groups of well defined clinical reactions.