The Journal of infectious diseases
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Randomized Controlled Trial Multicenter Study Comparative Study Clinical Trial
Valacyclovir and acyclovir for suppression of shedding of herpes simplex virus in the genital tract.
Valacyclovir exhibits better oral absorption and higher, more prolonged serum concentrations than oral acyclovir. The efficacy of valacyclovir and acyclovir on genital herpes simplex virus (HSV) shedding was assessed in a double-blind, 3-period crossover trial. ⋯ Although the suppression of viral replication is not complete, valacyclovir and acyclovir are highly effective in suppressing the frequency and quantity of genital HSV shedding.