Yonsei medical journal
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Yonsei medical journal · Apr 2020
ReviewNusinersen as a Therapeutic Agent for Spinal Muscular Atrophy.
The reduction of survival motor neuron (SMN) protein causes spinal muscular atrophy (SMA), an autosomal recessive neuromuscular disease. Nusinersen is an antisense oligonucleotide, approved by the FDA, which specifically binds to the repressor within SMN2 exon 7 to enhance exon 7 inclusion and augment production of functional SMN protein. ⋯ This review of nusinersen will discuss its action mechanism, cellular uptake, trafficking mechanisms, and administration approaches to cross the blood-brain barrier. Furthermore, nusinersen clinical trials will be assessed in terms of pharmacokinetics, tolerability and safety, the clinical outcomes of multiple intrathecal doses, and a discussion on the primary and secondary endpoints.
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Yonsei medical journal · Apr 2020
ReviewRisk Factors Associated with Endometrial Pathology in Premenopausal Breast Cancer Patients Treated with Tamoxifen.
To evaluate factors associated with endometrial pathology during tamoxifen use in premenopausal breast cancer (BC) patients. ⋯ In premenopausal BC patients treated with tamoxifen, abnormal uterine bleeding, increased endometrial thickness, and chemotherapy for BC were associated with the occurrence of endometrial cancer. These findings may provide useful information for gynecologic surveillance and counseling during tamoxifen treatment in premenopausal BC patients.
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Yonsei medical journal · Apr 2020
Randomized Controlled TrialEffects of Indoor Air Purifiers on Children with Asthma.
To evaluate the effects of air purifiers on the concentrations of indoor air pollutants and on asthma control in children. ⋯ This study suggests that air purifiers benefit medication burden in children with asthma by reducing PM2.5 levels.
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Yonsei medical journal · Apr 2020
Surgical Outcomes of Dysphagia Provoked by Diffuse Idiopathic Skeletal Hyperostosis in the Cervical Spine.
This study aimed to predict the surgical outcomes of diffuse idiopathic skeletal hyperostosis (DISH)-related dysphagia (DISH-phagia) and to evaluate the importance of prevertebral soft tissue thickness (PVST). ⋯ Surgical removal of anterior osteophytes is an effective treatment option for DISH-phagia, and PVST is a useful parameter in DISH-phagia. The goal of DISH surgery should be to remove DISH as much as possible to ensure sufficient PVST postoperatively.
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Yonsei medical journal · Apr 2020
Comparative StudyComparison of In Vivo Pharmacokinetics and Pharmacodynamics of Vancomycin Products Available in Korea.
Few studies have been investigated the in vivo efficacy of generic vancomycin products available outside of the United States. In this study, we aimed to compare the in vivo pharmacokinetics (PK) and pharmacodynamics (PD) of five generic vancomycin products available in Korea with those of the innovator. ⋯ Some generic vancomycin products available in Korea showed inferior PK and PD profiles, especially in mice infected with hetero-vancomycin-resistant Staphylococcus aureus.