Restorative neurology and neuroscience
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Restor. Neurol. Neurosci. · Jan 2019
Randomized Controlled Trial Multicenter StudyClinical improvement with intensive robot-assisted arm training in chronic stroke is unchanged by supplementary tDCS.
Intensive robot-assisted arm training in the chronic phase of stroke recovery can lead to clinical improvement. Combinatorial therapeutic approaches are sought to further optimize stroke recovery. Transcranial direct current stimulation (tDCS) is one candidate to combine with robotic training, as transient increases in excitability and improvements in motor behavior have separately been reported. ⋯ Our study confirms the benefit of intensive robot-assisted training in stroke recovery, and indicates that conventional tDCS does not confer further advantage to robotic training. We also showed that corticospinal integrity, as assessed by TMS, is a predictor of clinically meaningful response to intensive arm therapy in chronic stroke.
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Restor. Neurol. Neurosci. · Jan 2012
Randomized Controlled Trial Multicenter StudyCounteracting tinnitus by acoustic coordinated reset neuromodulation.
Subjective tinnitus is associated with pathologic enhanced neuronal synchronization. We used a model based desynchronization technique, acoustic coordinated reset (CR) neuromodulation, to specifically counteract tinnitus-related neuronal synchrony thereby inducing an unlearning of pathological synaptic connectivity and neuronal synchrony. ⋯ The CR-induced reduction of tinnitus and underlying neuronal characteristics indicates a new non-invasive therapy which might also be applicable to other conditions with neuronal hypersynchrony.