European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry
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Eur Arch Paediatr Dent · Oct 2015
Randomized Controlled Trial Comparative StudyA comparison of the sedative effect of oral versus nasal midazolam combined with nitrous oxide in uncooperative children.
To compare a combination of oral midazolam (0.2 mg/kg body weight) and nitrous oxide-oxygen sedation with a combination of intranasal midazolam (0.1 mg/kg body weight) and nitrous oxide-oxygen sedation for effectiveness, patient acceptability and safety profile in controlling the behaviour of uncooperative children. ⋯ The intranasal route of midazolam administration has a quick onset of action and a quick recovery of the patient from sedation as compared to the oral route of midazolam administration. Midazolam administered through the intranasal route is as effective as the oral route at a lower dosage. Therefore, it is an effective alternative to oral route for a paediatric dental situation.