Surgery
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Randomized Controlled Trial Clinical Trial
The effect of prolonged euglycemic hyperinsulinemia on lean body mass after severe burn.
The hypermetabolic response to burn increases protein catabolism. Euglycemic hyperinsu-linemia with exogenous insulin maintains muscle protein by continued stimulation of net protein synthesis. Our aim was to determine the effect of euglycemic hyperinsulinemia over the entire hospitalization on muscle anabolism by investigating lean body mass (LBM) as the primary endpoint. ⋯ Euglycemic hyperinsulinemia throughout the hospital course mitigates muscle catabolism and preserves lean body mass.