Surgery
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Randomized Controlled Trial
Intensive insulin treatment increases donor site wound protein synthesis in burn patients.
In the treatment of burns, patients' own skin is the preferred material to cover burn wounds, resulting in the need to create a donor site wound. Enhancement of healing of the donor site wound would be beneficial in burn patients. Insulin, an anabolic agent, is used routinely to treat hyperglycemia after injury. We investigated whether intensive insulin treatment increases fractional synthesis rate (FSR) of the donor site wound protein and decreases the length of hospitalization normalized for total body surface area burned (LOS/TBSA). ⋯ Insulin treatment increased FSR of the donor site wound protein in the early period of wound healing; FSR correlated with LOS/TBSA independent of the treatment regimen.
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Randomized Controlled Trial Comparative Study
A comparative study between 1 and 2 effective doses of rocuronium for intraoperative neuromonitoring during thyroid surgery.
The goal of this study was to explore an ideal application of rocuronium to enable adequate muscle relaxation for intubation without significantly affecting the evoked potentials measured by intraoperative neuromonitoring during thyroid surgery. ⋯ A total of 1 ED(95) of rocuronium (0.3 mg/kg) is an optimal dose for intraoperative neuromonitoring during thyroid surgery. Positive and high EMG signals were obtained in all patients at an early stage of operation, and satisfactory intubating conditions were achieved in most patients.