Archives of general psychiatry
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Arch. Gen. Psychiatry · Jan 2009
Randomized Controlled TrialDistinct effects of {delta}9-tetrahydrocannabinol and cannabidiol on neural activation during emotional processing.
Cannabis use can both increase and reduce anxiety in humans. The neurophysiological substrates of these effects are unknown. ⋯ Delta9-Tetrahydrocannabinol and CBD had clearly distinct effects on the neural, electrodermal, and symptomatic response to fearful faces. The effects of CBD on activation in limbic and paralimbic regions may contribute to its ability to reduce autonomic arousal and subjective anxiety, whereas the anxiogenic effects of Delta9-THC may be related to effects in other brain regions.