Archives of general psychiatry
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Arch. Gen. Psychiatry · Aug 2010
Randomized Controlled Trial Multicenter Study Comparative StudyCost-effectiveness analysis of a rural telemedicine collaborative care intervention for depression.
Collaborative care interventions for depression in primary care settings are clinically beneficial and cost-effective. Most prior studies were conducted in urban settings. ⋯ In rural settings, a telemedicine-based collaborative care intervention for depression is effective and expensive. The mean base case result was $85 634/QALY, which is greater than cost per QALY ratios reported for other, mostly urban, depression collaborative care interventions.
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Arch. Gen. Psychiatry · Aug 2010
Randomized Controlled Trial Comparative StudyA randomized add-on trial of an N-methyl-D-aspartate antagonist in treatment-resistant bipolar depression.
Existing therapies for bipolar depression have a considerable lag of onset of action. Pharmacological strategies that produce rapid antidepressant effects-for instance, within a few hours or days-would have an enormous impact on patient care and public health. ⋯ In patients with treatment-resistant bipolar depression, robust and rapid antidepressant effects resulted from a single intravenous dose of an N-methyl-D-aspartate antagonist.