Thorax
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Multicenter Study Observational Study
Short-term clinical outcome of normotensive patients with acute PE and high plasma lactate.
Strategies for identifying normotensive patients with acute symptomatic PE at high risk of PE-related complications remain to be defined. ⋯ Plasma lactate represents a powerful predictor of short-term PE-related complications and may provide guidance for decision-making in PE care.
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The promise of benefits from lung cancer screening is tempered by the false positive rate and the need to perform diagnostic procedures to determine the aetiology of the solitary pulmonary nodules (SPN) identified. We have developed a novel procedure which allows sampling of SPNs via a transparenchymal approach, and report the results from this as a first in human trial. ⋯ This first in human study demonstrates that bronchoscopic transparenchymal access of SPNs is feasible.
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Observational Study
Lung structure-function correlation in patients with primary ciliary dyskinesia.
Primary ciliary dyskinesia (PCD) is a rare disease, characterised by chronic airway infection. In cystic fibrosis, FEV1 is insensitive to detect patients with structural damage, and Lung Clearance Index (LCI) was proposed as a better marker of early lung damage. In PCD, the relationship between functional and structural abnormalities has been less studied. We aimed to re-examine this in a cohort of children and adults with mild to moderate PCD. ⋯ We demonstrated that measuring LCI in patients with PCD is of clinical relevance; it was more frequently abnormal than FEV1, correlated well with CFCT and was more sensitive than FEV1 to detect patients with structural abnormalities.
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Biography Historical Article
The centenary (2015) of the transfer factor for carbon monoxide (T(LCO)): Marie Krogh's legacy.