The Journal of clinical dentistry
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Randomized Controlled Trial Comparative Study Clinical Trial
Comparative efficacy of a new battery-powered toothbrush and a commercially available manual toothbrush on the removal of established supragingival plaque: a single-use crossover study in adults.
The objective of this single-use, examiner-blind, two-treatment crossover clinical study was to evaluate the efficacy of a new battery-powered toothbrush (Colgate MicroSonic) relative to that of a currently marketed manual toothbrush (Oral-B Indicator) for the removal of supragingival plaque. This study included the assessment of plaque removal in the whole mouth, at the gumline, and at interproximal sites via the comparison of pre- and post-brushing plaque levels measured using the Rustogi Modification of the Modified Navy Plaque Index. ⋯ The results of this study support the conclusion that the new Colgate MicroSonic battery-powered toothbrush provides a clinically acceptable level of efficacy for the removal of supragingival plaque. Further, the Colgate MicroSonic battery-powered toothbrush exhibited significantly greater levels of efficacy for the removal of supragingival plaque when compared to the Oral-B Indicator Toothbrush.
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Randomized Controlled Trial Comparative Study
A study of benzocaine gel dosing for toothache.
This pilot study evaluated subject compliance with a proposed OTC label with improved dosing directions for self-application of a 20% benzocaine gel for toothache pain, and assessed the methodology for evaluating efficacy in a future pivotal study of benzocaine gel. It was hypothesized that > or = 75% of subjects would apply < or = 400 mg of product (80 mg benzocaine). Exploratory analyses of efficacy were also performed. ⋯ The improved dosing directions resulted in a high percentage of subjects self-applying an appropriate amount of benzocaine gel or matching placebo. The label and study methodology appear suitable for a pivotal dose-response study in subjects with toothache pain. While the current study was not statistically powered to make firm efficacy conclusions, 20% benzocaine gel appeared more efficacious than placebo, providing a rapid onset of pain relief and a relatively long duration of action.
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Randomized Controlled Trial
Comparison of irrigation to floss as an adjunct to tooth brushing: effect on bleeding, gingivitis, and supragingival plaque.
The purpose of this twenty-eight day, randomized, single-blind clinical trial was to assess the efficacy of the addition of daily oral irrigation to both power and manual tooth brushing, compared to a traditional regimen of manual tooth brushing and flossing, to determine which regimen had the greatest effect on the reduction of gingival bleeding, gingivitis, and supragingival plaque. ⋯ The results of this clinical trial indicate that when combined with manual or sonic tooth brushing, oral irrigation is an effective alternative to manual tooth brushing and dental floss for reducing bleeding, gingival inflammation, and plaque removal.