Transfusion
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Randomized Controlled Trial Clinical Trial
A randomized controlled trial oftransfusion-related acute lung injury: is plasma from multiparous blood donors dangerous?
Transfusion-related acute lung injury (TRALI) and other posttransfusion reactions may be caused by granulocyte and/or HLA antibodies, which are often present in blood from multiparous donors. The purpose of this study was to compare the effects of plasma from multiparous donors with those of plasma from donors with no history of transfusion or pregnancy (control plasma) in a prospective, randomized, double-blind, crossover study. ⋯ Plasma from multiparous blood donors may impair pulmonary function in intensive care unit patients.