Archives of neurology
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Archives of neurology · Sep 2010
Randomized Controlled TrialA randomized controlled double-masked trial of albuterol add-on therapy in patients with multiple sclerosis.
Interleukin 12 (IL-12), a cytokine that promotes generation of helper T cells subtype 1, is increased in multiple sclerosis. Albuterol sulfate, a β2-adrenergic agonist, reduces IL-12 expression, so we tested the effect of albuterol as an add-on treatment to glatiramer acetate therapy. ⋯ Treatment with glatiramer acetate plus albuterol is well tolerated and improves clinical outcomes in patients with multiple sclerosis.