Zentralblatt für Gynäkologie
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Multicenter Study Clinical Trial
[Treatment of uterine leiomyoma with depot leuprorelin acetate (Enantone-Gyn monthly depot). Effect on leiomyoma volume and operability. German Leuprorelin Study Group].
In an open, non-comparative clinical phase IV multicentre study the efficacy and safety of the GnRH agonist leuprorelin acetate depot (LAD) for patients with at least one symptomatic uterine leiomyoma was assessed. 144 premenopausal patients were enrolled and treated with up to six injections of 3.75 mg LAD/month subcutaneously prior to surgical intervention, e.g. either hysterectomy or myoma enucleation. Due to a profound suppression of serum-estradiol levels to castration range (< or = 30 pg/ml) an average volume reduction of all myomas from 86.6 +/- 101.3 ml to 38.5 +/- 63.5 ml became obvious for 90% of all patients. In parallel a significant shrinkage of uterine volume was observed. ⋯ Treatment was generally well tolerated. Most of the observed side effects were related to hypoestrogenism. The results of this study have shown that medical pretreatment for patients with uterine fibroids with LAD prior to surgical intervention is an effective measure to improve operability and could lead for several patients to minimal invasive surgery.
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Survey about oral contraceptives and postmenopausal hormonal replacement therapy and the effects on coagulation system. The question to withdraw oral contraceptives 4 weeks before a gynecological operation cannot be answered sufficiently. ⋯ It can be anticipated, that this rule will be changed in future. There are no scientific hints, which could bring a phlebitis or varicosis in connection etiologically with a thromboembolic disorder during oral contraceptives.
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Randomized Controlled Trial Comparative Study Clinical Trial
[Gameprost, sulproston and dinoproston for induced abortion in the 15th-24th week of pregnancy].
In a randomized, prospective study at the Dept. of Obstetrics and Gynecology of the University Hospital of Giessen 4 different ways of inducing abortions with prostaglandins were tested between the 15th and 24th week of gestation. The aim of the study was to determine the best approach to inducing abortion in order to minimize the psychological and physical stress to the patient. Subjects randomized to the first two groups got a single cervical installation of either 0.5 mg Dinoprostongel (Prepidil, N = 22) or 0.5 mg Sulprostongel (Nalador, N = 21). ⋯ We conclude that repetitive application of Gemeprost vaginal suppositories decreases the time to abortion and subject discomfort tremendously. The application of Gemeprost suppositories provides the easiest and most efficient therapeutic approach for both patients and staff. Furthermore the regiment that provided the best results was also the most cost-effective (range 180,-DM to 317,- DM per case).
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Review Comparative Study
[Ablative versus conservative therapy of operable breast cancer].
Review about operative management of breast cancer. Comparison between breast preserving therapy and mastectomy in respect of the results of the studies of Veroneti and B. Fisher.
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Randomized Controlled Trial Clinical Trial
[Effect of Urapidil in antihypertensive therapy of preeclampsia on newborns].
For the therapy of preeclamptic patients is Urapidil besides Dihydralazine another possible option for iv-therapy with good results in first clinical studies. Effects of both drugs on the newborns were observed. - ⋯ With Urapaidil we have another therapeutic option in preeclampsia where we could not show any negative side-effects on the newborns.