The American journal of gastroenterology
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Am. J. Gastroenterol. · Apr 2006
Randomized Controlled TrialInfluence of motilin on gastric fundus tone and on meal-induced satiety in man: role of cholinergic pathways.
Motilin agonists are strong gastroprokinetics, but their impact on symptoms in delayed gastric emptying has been disappointing. It has been speculated that it is due to the contractile effect of motilin agonists on the proximal stomach, but the pathway involved and the symptomatic consequences have been incompletely elucidated. ⋯ Administration of motilin causes a contraction of the proximal stomach in humans and increases meal-induced satiety. The effect of motilin is atropine-resistant and involves a direct muscular pathway or a non-cholinergic neural pathway.