The American journal of gastroenterology
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Am. J. Gastroenterol. · Jan 2010
Review Meta AnalysisEmpiric quadruple vs. triple therapy for primary treatment of Helicobacter pylori infection: Systematic review and meta-analysis of efficacy and tolerability.
Recent treatment guidelines recommend two first-line therapies for Helicobacter pylori infection: proton pump inhibitor (PPI), bismuth, tetracycline, and metronidazole (quadruple therapy) or PPI, clarithromycin, and amoxicillin (triple therapy). We performed a systematic review and meta-analysis to compare the efficacy and tolerability of these regimens as first-line treatment of H. pylori. ⋯ Quadruple and triple therapies yielded similar eradication rates as primary therapy for H. pylori infection. Both therapies yielded suboptimal eradication rates. Patient compliance and side effects are similar for quadruple and triple therapies.
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Am. J. Gastroenterol. · Jan 2010
Classification of the severity of acute pancreatitis: how many categories make sense?
There is an ongoing effort to revise the 1992 Atlanta classification of acute pancreatitis in the light of emerging evidence. The categorization of the severity of acute pancreatitis is one of the key elements of the classification. This paper aims to define the optimal number of categories and provide their definitions on sound clinical grounds.
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Am. J. Gastroenterol. · Jan 2010
A population-based study of pyogenic liver abscesses in the United States: incidence, mortality, and temporal trends.
Few population-based studies have evaluated pyogenic liver abscess (PLA) in North America. We assessed the incidence of PLA and evaluated predictors of mortality. ⋯ The incidence of PLA is increasing and is associated with significant mortality that is attributable to several modifiable risk factors.