The American journal of gastroenterology
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Am. J. Gastroenterol. · Jun 2012
Randomized Controlled TrialSaccharomyces boulardii for the prevention of antibiotic-associated diarrhea in adult hospitalized patients: a single-center, randomized, double-blind, placebo-controlled trial.
Antibiotic-associated diarrhea (AAD) and Clostridium difficile-associated diarrhea (CDAD) are common complications of antibiotic use. Probiotics were effective in preventing AAD and CDAD in several randomized controlled trials. This study was aimed at testing the effect of Saccharomyces boulardii on the occurrence of AAD and CDAD in hospitalized patients. ⋯ In elderly hospitalized patients, S. boulardii was not effective in preventing the development of AAD.