The American journal of gastroenterology
-
Am. J. Gastroenterol. · Feb 2019
Meta AnalysisProkinetics for Functional Dyspepsia: A Systematic Review and Meta-Analysis of Randomized Control Trials.
Prokinetics are recommended for the treatment of functional dyspepsia (FD) but systematic reviews give conflicting results on the efficacy of these agents. We have therefore conducted an updated systematic review to support the 2017 joint ACG/CAG dyspepsia guidelines. ⋯ From the current evidence, prokinetics may be effective for the treatment in all subtypes of FD, with very low quality of evidence. There was no difference between prokinetics for dyspeptic symptom improvement. High-quality RCTs with large sample sizes of FD patients are needed to verify the efficacy of prokinetics.