The British journal of ophthalmology
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Bevacizumab for Coats' disease with exudative retinal detachment and risk of vitreoretinal traction.
To evaluate the effect of supplemental intravitreal bevacizumab for management of Coats' disease. ⋯ Coats' disease treated with intravitreal bevacizumab in addition to standard therapy can develop to vitreoretinal fibrosis and potentially traction retinal detachment. These tractional features are not often found in Coats' disease treated with standard measures without bevacizumab. Caution is advised in the use of bevacizumab for patients with Coats' disease.
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Oculopharyngeal muscular dystrophy (OPMD) presents with progressive ptosis, dysphagia and limb girdle weakness, and is caused by expansion of a trinucleotide tandem repeat within the gene encoding poly-(A) binding protein 2. ⋯ OPMD could have been diagnosed earlier in every patient in this case series. Greater awareness of OPMD among ophthalmologists, gastroenterologists and otolaryngologists may lead to earlier diagnosis, improved management and avoidance of unnecessary investigations.
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Coccidioidomycosis can simulate an intraocular neoplasm. We reviewed a case report of a 10-year-old girl who was referred with an intraocular tumour. This tumour consisted of a coccidioidomycosis infection in the eye. The eye was blind and painful so it was removed.
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Randomized Controlled Trial Comparative Study
Two-quadrant high-volume sub-Tenon's anaesthesia for vitrectomy: a randomised controlled trial.
Total volume using a standard single inferonasal injection for sub-Tenon's anaesthesia is limited by an increase in intraocular pressure (IOP) and commonly requires the operating surgeon to top-up the block intraoperatively. This study compares the efficacy and safety of a two-quadrant technique that allows the use of a higher volume of local anaesthetic. ⋯ Two-quadrant sub-Tenon's anaesthesia using 10 ml of a 50:50 mixture of 2% lidocaine and 0.5% bupivacaine with 150 IU hyaluronidase seems to be more effective than a single-quadrant technique at reducing intraoperative and postoperative pain during vitrectomy.
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Controlled Clinical Trial
Optic nerve sheath diameter in normal-tension glaucoma patients.
To report on the optic nerve sheath diameter (ONSD) in patients with normal-tension glaucoma (NTG) compared with controls without known optic nerve (ON) or intracranial disease. ⋯ An increased ONSD is generally associated with increased intracranial pressure; however, ONSDs in a group of NTG patients also were significantly increased compared with controls. ON sheath compartmentation and thinning of the ON sheath are two possible explanations for an increase in the ONSD in patients with NTG.