The British journal of ophthalmology
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Multicenter Study
Diet patterns and the incidence of age-related macular degeneration in the Atherosclerosis Risk in Communities (ARIC) study.
Age-related macular degeneration (AMD) is the leading cause of irreversible vision loss among the elderly. ⋯ Diet patterns were not significantly associated with incident any or incident early AMD. However, consumption of a Western pattern diet may be a risk factor for development of late AMD.
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To develop a deep learning system (DLS) that can automatically detect malignant melanoma (MM) in the eyelid from histopathological sections with colossal information density. ⋯ Our DLS, which uses artificial intelligence, can automatically detect MM in histopathological slides and highlight the lesion area on WSIs using a probabilistic heatmap. In addition, our approach has the potential to be applied to the histopathological sections of other tumour types.
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Multicenter Study
Unmeasurable small size superficial and deep foveal avascular zone in nanophthalmos: the Collaborative Nanophthalmos OCTA Study.
To study the macular structure and vasculature in consecutive nanophthalmic eyes using optical coherence tomography angiography. ⋯ FAZ attenuation, capillary tortuosity, foveal folds and thickened subfoveal choroid characterise the nanophthalmic macula. These findings may result from a redundant retina and the absence of apoptotic foveolar retraction because of developmental arrest of the optic vesicle after closure of the embryonic fissure.
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Multicenter Study Comparative Study
Adalimumab for the treatment of refractory active and inactive non-infectious uveitis.
To compare the efficacy of adalimumab in eyes with active and inactive non-infectious uveitis in the real-world setting. ⋯ Adalimumab appears to reduce the corticosteroid burden in active and inactive non-infectious uveitis in the real-world setting. Inflammatory activity at the time of adalimumab commencement may determine long-term treatment success.
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Multicenter Study
Distal enlargement of the optic nerve sheath in the hyperacute stage of intracerebral haemorrhage.
Optic nerve sheath diameter (ONSD) enlargement is detectable in patients with increased intracranial pressure. The aim was to detect an enlargement of the ONSD using optic nerve sonography in patients with acute intracerebral haemorrhage (ICH) within 6 h of the onset of symptoms. ⋯ Sonographically measured enlargement of the ONSD may already be detectable in the hyperacute stage of increased intracranial pressure.