Przegla̧d epidemiologiczny
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The paper presents contemporary definitions and guidelines for management of severe sepsis and septic shock in neonates. We discuss main directions of hemodynamic resuscitation, antibacterial and supportive treatment. Pathophysiological differences of septic shock in this group of patients were described.
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At present, the only reasonable action which reduces the case fatality rate at patients with severe sepsis and septic shock is the early diagnosis of infection which allows to introduce effective therapy. Although sepsis is a typical clinical syndrome recognized in connection with infection, it should be remembered that infection does not reveal itself in each case. ⋯ In view of few characteristic, especially in the initial phase of sepsis, clinical symptoms, laboratory investigations describing the present state of immune response of organism find a huge application. In our work we made an attempt to bring closer the latest markers of inflammatory reaction and infection such as acute phase proteins procalcytonin (PCT), proANP and lipopolisacharyde binding protein (LBP).