Acta anaesthesiologica Sinica
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Acta Anaesthesiol. Sin. · Mar 2002
Randomized Controlled Trial Comparative Study Clinical TrialA comparative study of the safety and efficacy of 0.5% levobupivacaine and 0.5% bupivacaine for epidural anesthesia in subjects undergoing elective caesarean section.
Levobupivacaine is the S(-)-enantiomer of the racemic bupivacaine. Data of pharmacological studies suggest that levobupivacaine has a lower potential of toxicity for central nervous and cardiovascular systems than does bupivacaine. The present study was undertaken to compare the safety and efficacy between levobupivacaine and bupivacaine in epidural anesthesia for Cesarean delivery. ⋯ The onset and fade-out of sensory and motor blockade, quality of anesthesia, muscle relaxation and overall quality of anesthesia as assessed were comparable between two groups. No significant maternal or neonatal adverse events were found between the treatment groups. In comparison, levobupivacaine had the efficacy and safety profile equivalent to bupivacaine in epidural anesthesia for Caesarean section.
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Acta Anaesthesiol. Sin. · Mar 2002
Randomized Controlled Trial Clinical TrialEffects of intravenous ketorolac and fentanyl combined with midazolam on analgesia and side effects during extracorporeal shock wave lithotripsy.
Extracorporeal shock wave lithotripsy (ESWL) is usually carried out on ambulatory or outpatient basis, and thus an appropriate anesthesia with minimal side effects is required. This study was to compare the analgesic and side effects of intravenous ketorolac with that of intravenous fentanyl, in combination with midazolam in ESWL. ⋯ Both intravenous ketorolac and fentanyl in combination with midazolam could provide good anesthesia for ESWL. However, ketorolac plus midazolam had less side effects and allowed shorter discharge time from PAR. We suggest that intravenous ketorolac combined with midazolam is a safe and effective anesthetic regiment for ESWL, particularly on ambulatory basis.