International journal of surgical investigation
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Int. J. Surg. Investig. · Jan 2000
Randomized Controlled Trial Clinical TrialPostoperative intramuscular dextromethorphan injection provides pain relief and decreases opioid requirement after modified radical mastectomy.
Narcotics are still the therapeutic mainstay for postoperative pain relief. However, many unwanted side effects are accompanied. NMDA antagonists have been demonstrated to produce analgesic and antihyperalgesic effects, moreover, to possess potentiated effect of narcotics on postoperative pain management. ⋯ Postoperative DM I.M. injection provided an analgesic effect and reduced meperidine requirement after MRM.
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Int. J. Surg. Investig. · Jan 2000
Randomized Controlled Trial Comparative Study Clinical TrialShort-term symptomatic outcome and quality of life after laparoscopic versus open Nissen fundoplication: a prospective randomized trial.
Laparoscopic operation has replaced conventional operation in the treatment of reflux disease. This change has been mostly based on excellent results from highly experienced antireflux surgeons rather than on randomized clinical trials. ⋯ LNF and ONF are effective methods in the operative treatment of GERD in short-term and result in a significant improvement in patients gastrointestinal symptoms and quality of life.