The American journal of pediatric hematology/oncology
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Am J Pediatr Hematol Oncol · Nov 1994
Case ReportsTyphlitis in a patient with acute lymphoblastic leukemia prior to the administration of chemotherapy.
A 3-year-old girl with acute lymphoblastic leukemia developed typhlitis immediately after diagnosis and before the institution of chemotherapy. ⋯ Typhlitis should always be considered as a potential cause of acute sepsis and abdominal pain in a leukemic patient.
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Am J Pediatr Hematol Oncol · Aug 1994
Current controversy: is computed tomography scan of the chest needed in patients with Wilms' tumor?
Reports from the National Wilms' Tumor Study (NWTS) Group on the subject of chest computed tomography (CT) versus chest radiograph for the detection of lung metastases from Wilms tumor are reviewed. ⋯ All children should have the benefit of the most sensitive imaging available, including CT, to detect tumor spread.
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Am J Pediatr Hematol Oncol · Aug 1994
Comparative StudyPrevention of chemotherapy-induced emesis with granisetron in children with malignant diseases.
In a prospective crossover study, we evaluated the safety and antiemetic activity of granisetron, a 5-hydroxytryptamine3 (5-HT3) receptor antagonist, compared with conventional antiemetics regimen, including metoclopramide, in pediatric cancer patients. ⋯ Granisetron 40 micrograms/kg is well tolerated and more effective than are conventional antiemetic regimens containing metoclopramide for children receiving cancer chemotherapy.
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Am J Pediatr Hematol Oncol · Aug 1992
Continuous epidural anesthesia for postoperative analgesia in the pediatric oncology patient.
When compared with conventional techniques, epidural anesthesia not only provides improved analgesia, but also has several beneficial effects on the postoperative respiratory, cardiovascular, and metabolic status of the patient. Although the efficacy of this technique in children has been demonstrated, extensive experience in the pediatric oncology patient has not been previously reported. We retrospectively reviewed our 2-year experience with epidural analgesia and discuss the techniques involved in implementing this service for the pediatric oncology patient. ⋯ Postoperative analgesia was provided by a continuous infusion of a bupivacaine/fentanyl mixture, supplemented with intermittent epidural fentanyl by bolus dose as needed. No complications related to epidural catheters were noted. Our review supports the efficacy of this technique for providing postoperative analgesia after various major surgical procedures in the pediatric oncology patient.
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Am J Pediatr Hematol Oncol · Jan 1990
Anesthesia for diagnostic and therapeutic procedures in pediatric outpatients.
Appropriate sedation of pediatric oncology patients during painful diagnostic and therapeutic procedures is a recognized problem. At the Memorial Sloan-Kettering Cancer Center the pediatric oncologists and anesthesiologists have developed a cooperative program that has provided safe and effective sedation of outpatients. ⋯ Procedures included lumbar puncture and/or intrathecal chemotherapy, multiple bone marrow aspirations, bone marrow biopsies, and removal of indwelling central vein catheters. Monitoring of patients during the procedures as well as various pharmacologic techniques to provide adequate working conditions are described.