Fortschritte der Medizin
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Fortschritte der Medizin · May 1998
Randomized Controlled Trial Multicenter Study Clinical Trial[Symptomatic local therapy of the uncomplicated common cold. Multicenter controlled study of the effectiveness of an antiseptic lozenge].
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Fortschritte der Medizin · Dec 1996
Randomized Controlled Trial Multicenter Study Comparative Study Clinical Trial[Flupirtine in comparison with chlormezanone in chronic musculoskeletal back pain. Results of a multicenter randomized double-blind study].
The analgesic and muscle-relaxing properties of flupirtine maleate, chlormezanone and placebo were compared in a total of 184 patients. Of these patients, 164 met the criteria of the treatment plan (intention to treat), and the data of 140 patients were finally evaluated in accordance with the test protocol. A positive response was defined as a reduction in pain intensity and muscle tension by 2 categories on the 5-category verbal scale "very severe/severe/moderate/mild/ none" on the seventh day of treatment. ⋯ In the per-protocol-analysis the responder rate was 60.9% for flupirtine, 47.8% for chlormezanone, and 43.8% for placebo, the difference between drugs and placebo not being significant. The overall assessment of the physicians involved was very good/ good in 47.8% and satisfactory in 37.0% of the flupirtine group, very good/good in 45.6% and satisfactory in 17.4% of the chlormezanone group, the corresponding figures for the placebo group being 33.4% and 20.6%, respectively. Flupirtine was thus superior to placebo (p = 0.007). The incidence of adverse drug reactions was 14.8% (8/54) for flupirtine, 19.3% (11/57) for chlormezanone, and 7.3% (4/55) for placebo.
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Fortschritte der Medizin · Jan 1996
Randomized Controlled Trial Comparative Study Clinical Trial[Education of paramedics in resuscitation: after 6 months some procedures forgotten. Knowledge and capability of medical lay personnel after education in cardiovascular resuscitation].
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Fortschritte der Medizin · Nov 1995
Randomized Controlled Trial Multicenter Study Clinical Trial[Effectiveness of flupirtine in chronic tension headache. Results of a double-blind study versus placebo].
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Fortschritte der Medizin · Oct 1994
Randomized Controlled Trial Comparative Study Clinical Trial[Hypervolemic hemodilution as a means of preventing homologous blood transfusion. A simple alternative to acute normovolemic hemodilution].
Acute normovolenic hemodilution (ANH) is timeconsuming and complicated, and has only a small effect in reducing the need for homologous blood. A simpler procedure is hypervolemic hemodilution (HHD). In the present prospective, randomized study, HHD is compared with ANH for its blood-saving effect. ⋯ HHD is just as effective as ANH for reducing homologous blood requirements, and is much simpler to apply.