Postȩpy higieny i medycyny doświadczalnej (Online)
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Postepy Hig Med Dosw (Online) · Aug 2016
ReviewBiochemistry and therapeutic potential of hydrogen sulfide - reality or fantasy?
Hydrogen sulfide (H2S) is a signaling gasotransmitter, involved in different physiological and pathological processes. H2S regulates apoptosis, the cell cycle and oxidative stress. H2S exerts powerful effects on smooth muscle cells, endothelial cells, inflammatory cells, endoplasmic reticulum, mitochondria and nuclear transcription factors. ⋯ However, recently results have demonstrated that H2S has protective action for ischemic heart disease or hypertension, and protects against ischemia of the brain. This review summarizes the negative and the positive roles of H2S in various biological systems, for example the cardiovascular system and nervous system. We also discuss the function of classical, therapeutic and natural (for example garlic) donors of H2S in pre-clinical and clinical studies.
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Postepy Hig Med Dosw (Online) · Jan 2015
Review[Hypothermia--mechanism of action and pathophysiological changes in the human body].
This review focuses on the physiological responses and pathophysiological changes induced by hypothermia. Normal body function depends on its ability to maintain thermal homeostasis. The human body can be divided arbitrarily into two thermal compartments: a core compartment (trunk and head), with precisely regulated temperature around 37°C, and a peripheral compartment (skin and extremities) with less strictly controlled temperature, and lower than the core temperature. ⋯ Classification by temperature is not universal. Lowering of body temperature disrupts the physiological processes at the molecular, cellular and system level, but hypothermia induced prior to cardiosurgical or neurosurgical procedures, by the decrease in tissue oxygen demand, can reduce the risk of cerebral or cardiac ischemic damage. Therapeutic hypothermia has been recommended as a clinical procedure in situations characterized by ischemia, such as cardiac arrest, stroke and brain injuries.
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Postepy Hig Med Dosw (Online) · Jun 2014
Review[Molecular diagnosis of food allergy--do we know more?].
Component-resolved diagnostics (CRD) is the research method that allows to determine the concentrations of specific immunoglobulin E against a particular allergenic components. The paper discusses the importance of CRD in the food allergy diagnosis to common animal and vegetable allergens. The capabilities of the method and its limitations in the application are presented. ⋯ Especially in situations of estimating the risk of severe allergic reactions. Despite these limitations, the CRD method is a modern tool to the current diagnosis of allergy deserving of its popularisation. It provides information on allergenic components at the molecular level, allowing better understanding of symptoms and patient adjusted procedures.
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Postepy Hig Med Dosw (Online) · Mar 2014
Review[Genetic and immunologic determinants of intravesical BCG therapy in non-muscle-invasive urothelial bladder cancer].
Bladder cancer (BCA) is one of the most common cancers. In 2010 in Poland, 6296 people developed bladder cancer and 3110 people died of it. Immunotherapy with BCG (Bacillus Calmette-Guérin) is by far the most effective adjuvant therapy. ⋯ This is evidenced by the presence of differences in genetic variants of cytokines correlated with the varied risk of bladder cancer incidence. It is believed that concentrations of particular cytokines in urine after installation of BCG may indicate response to the therapy. Increased levels of Th1 cytokines - IFN-γ, IL-2 and TNF-α are correlated with longer survival time without recurrence, whereas high levels of Th2 cytokines such as IL-10, predict unsuccessful BCG therapy.
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Postepy Hig Med Dosw (Online) · Jan 2014
Review Comparative StudyUsefulness of estimation of blood procalcitonin concentration versus C-reactive protein concentration and white blood cell count for therapeutic monitoring of sepsis in neonates.
This study was intended to assess the clinical usefulness of blood procalcitonin (PCT) concentrations for the diagnosis and therapeutic monitoring of nosocomial neonatal sepsis. ⋯ Procalcitonin concentrations in blood appear to be of use for the diagnosis and therapeutic monitoring of nosocomial infections in neonates as this parameter demonstrates greater sensitivity and specificity than C-reactive protein. White blood cell counts appear to be of little diagnostic value in the early phase of infection or for therapeutic monitoring.