British heart journal
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British heart journal · Jun 1993
Randomized Controlled Trial Clinical TrialAspirin does not improve early arterial patency after streptokinase treatment for acute myocardial infarction.
To investigate the hypothesis that the magnitude of the life saving effect of aspirin in the second international study of infarct survival (ISIS-2) trial cannot be explained solely by prevention of late reocclusion of the infarct related artery. The aim of this study was to discover whether or not aspirin in combination with streptokinase had an adjuvant thrombolytic effect. ⋯ The magnitude of the life saving effect of aspirin remains unexplained. Further investigation is needed into the mechanism of action of antiplatelet treatment in relation to thrombolytic treatment.