Scandinavian journal of gastroenterology. Supplement
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Scand. J. Gastroenterol. Suppl. · Jun 1981
Comparative StudyThe new histamine H2-receptor antagonist ranitidine. Duration of action.
The antisecretory effects of a new histamine H2-receptor antagonist ranitidine hydrochloride 150 mg, have been tested on basal and pentagastrin-stimulated acid secretion in healthy volunteers 5 and 10 h after oral administration. In addition, the 24 h intragastric pH-profiles have been measured in patients undergoing parenteral nutrition after three oral doses of ranitidine 150 mg per day. ⋯ The intragastric pH remained above 5 for at least 24 h. Ranitidine has proven to be a more potent and longer acting antisecretory compound than cimetidine.