Magma (New York, N.Y.)
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Magma (New York, N.Y.) · Feb 2012
Residual tumor after laser ablation of human non-small-cell lung cancer demonstrated by ex vivo staining: correlation with invasive temperature measurements.
Histology is the gold standard for confirming thermally induced necrosis. Generally, however, no specimen is obtained from thermal ablation therapy for pathological examination. The aim of this study was to provide evidence for the relationship between temperatures reached and resulting tissue coagulation during laser ablation in a near-physiological ex vivo lung tumor model by combining viability staining and direct temperature measurement. ⋯ We found that coagulation size correlated positively with temperature. There was a clear trend towards the correlation of time over 44°C and ablation depth. Maximum temperatures did not significantly correlate with coagulation size. Laser ablation of lung tumors using the IHLP (isolated human lung perfusion) model represents a possible method for evaluating ex vivo the interrelationships of temperature, time of temperature exposure, and resulting coagulation.
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Magma (New York, N.Y.) · Feb 2012
Comprehensive analysis of the Cramer-Rao bounds for magnetic resonance temperature change measurement in fat-water voxels using multi-echo imaging.
The aim of this paper is to characterize the noise propagation for MRI temperature change measurement with emphasis on finding the best echo time combinations that yield the lowest temperature noise. ⋯ The results present a comprehensive analysis of the effects of different scan parameters on temperature noise, potentially benefiting the selection of scan parameters for clinical MRI thermometry.